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Flora Jow Selected Research

Schizophrenia (Dementia Praecox)

11/2012N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward an α7 nicotinic acetylcholine receptor agonist preclinical candidate.
12/2011Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625.
3/2009Old and new pharmacology: positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the 5-hydroxytryptamine(2B/C) receptor antagonist SB-206553 (3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']di pyrrole-1(2H)-carboxamide).

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Flora Jow Research Topics

Disease

3Cognitive Dysfunction
11/2012 - 06/2010
3Schizophrenia (Dementia Praecox)
11/2012 - 03/2009
2Alzheimer Disease (Alzheimer's Disease)
11/2012 - 03/2009
1Seizures (Absence Seizure)
03/2008
1Ischemic Stroke
01/2008

Drug/Important Bio-Agent (IBA)

3alpha7 Nicotinic Acetylcholine ReceptorIBA
12/2011 - 03/2009
2Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA
11/2012 - 12/2011
11- (6- (4- fluorophenyl)pyridin- 3- yl)- 3- (4- piperidin- 1- ylbutyl)ureaIBA
12/2011
1Antipsychotic Agents (Antipsychotics)IBA
12/2011
1Pentylenetetrazole (Metrazol)IBA
03/2008
1ImmunophilinsIBA
01/2008
1TOR Serine-Threonine KinasesIBA
01/2008
1LigandsIBA
01/2008
1Sirolimus (Rapamycin)FDA Link
01/2008